When did the first outbreak of the Bubonic Plague occur in the Byzantine Empire? 3 AD 541 AD 1756 AD 1899 AD None Which Byzantine emperor was in power during the first outbreak of the Bubonic Plague? Constantine I Theodosius II Justinian I Heraclius None What was the estimated death toll of the Bubonic Plague during the Plague of Justinian? 1 million 10 million 25 million 50 million None How did the Bubonic Plague primarily spread throughout the Byzantine Empire? Airborne transmission Contaminated water Fleas on rats Direct human contact None What long-term impact did the Bubonic Plague have on the Byzantine economy? Increased agricultural output Strengthened military power Severe economic decline Enhanced trade routes None Time's up
