Who commissioned the Lewis and Clark Expedition to explore the newly acquired Louisiana Purchase? Thomas Jefferson James Madison Alexander Hamilton John Adams None What river did Lewis and Clark follow for a significant portion of their journey to the Pacific Ocean? Mississippi River Columbia River Missouri River Ohio River None Who served as the primary guide and interpreter for Lewis and Clark, contributing to successful interactions with Native American tribes? Sacagawea Sitting Bull Pocahontas Tecumseh None Which mountain range did the expedition cross to reach the Pacific Ocean? Rocky Mountains Appalachian Mountains Sierra Nevada Mountains Cascade Range None What was the name of the fort built by Lewis and Clark on the Oregon Coast, where they spent the winter of 1805–1806? Fort Astoria Fort Clatsop Fort Vancouver Fort Lewis None Time's up
